Inherited Risk Factors in Femoropopliteal Peripheral Arterial Occlusive Disease Patients Under 55 Years

Purpose: We aimed in this study to examine the presence and frequency of genetic polymorphisms in individuals less than 55 years of age with significant peripheral arterial disease in the femoropopliteal arterial system and to report on their association with the disease. Material and methods: This cross-sectional study undertaken between 2013 and 2014 included a total of 32 peripheral arterial disease patients (30 male, mean age 47.34±4, 62 years) were included. Less than 55 years of age who had significant femoropopliteal stenosis/occlusion (> 50%) as documented by a computed tomography arteriography and who had a complete set of thrombophilia marker and genetic risk factor analysis results. Results: A total of 32 patients were investigated for genetic risk factors and thrombophilia markers. Of the 32 patients 7 (21.8%) had factor V Leiden mutation (7 heterozygous), 2 (6.2%) had prothrombin gene mutation, and 13 (40.6%) had methylenetetrahydrofolate reductase C677T gene mutation (3 homozygous and 10 heterozygous). Three patients had both legs involved, while 18 and 11 patients had involvement on the right and left side only, respectively. Conclusion: Due to the presence of an association between risk factors for hereditary thrombophilia and thrombotic and occlusive events, which lead to increased failure rates in operations and interventions for peripheral arterial disease, we believe that thrombophilic markers and genetic risk factors should certainly be assessed particularly in younger patients and/or patients undergoing revascularization procedures to improve success and patency rates and to minimize thrombotic and occlusive complications.